WATER-SOLUBLE POWDERS FOR ORAL SOLUTION AND USE THEREOF

摘要

Described are novel water-soluble powder or granular pharmaceutical forms for use in veterinary medicine containing therapeutically effective amounts of amoxicillin trihydrate and potassium clavulanate in composition with a filler acceptable in veterinary medicine and with at least one buffering agent suitable for maintaining the pH value of the medium between 6.0 and 8.5 at a quick and complete dissolution of the given pharmaceutical forms in drinking water for animals. After dissolution in water the clear solutions are stable for at least 24 hours. Preferably there are used phosphate buffers, preferably monosodium dihydrogen phosphate dihydrate/sodium hexametaphosphate buffer, which maintain the pH values of the aqueous medium between 6.5 and 7.5, preferably about 7.0. In accordance with the aim of the invention there is avoided the formation of suspensions that are known for causing problems in water tanks for cattle, namely formation of sediments on the bottom of the tanks with resulting technical problems such as clogging of installations or plumbing for administering drinking water to animals.