发明名称 |
Process for preparing nateglinide and intermediates thereof |
摘要 |
Provided is a process for preparation of an intermediate in the synthesis of nateglinide. Trans-4-isopropylcyclohexane acid chloride is formed by reacting 4-isopropylcyclohexanecarboxyl acid with thionyl chloride in the presence of an effective amount of an organic amide. Also provided are processes for preparation of nateglinide by acylation of a suitable salt of D-phenylalanine with trans-4-isopropylcyclohexane acid chloride in both a single and a two phase system, and in water free of a co-solvent.
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申请公布号 |
US2004152782(A1) |
申请公布日期 |
2004.08.05 |
申请号 |
US20030614266 |
申请日期 |
2003.07.03 |
申请人 |
YAHALOMI RONIT;SHAPIRO EVGENY;DOLITZKY BEN-ZION;GOZLAN YIGAEL |
发明人 |
YAHALOMI RONIT;SHAPIRO EVGENY;DOLITZKY BEN-ZION;GOZLAN YIGAEL |
分类号 |
A61K31/16;A61K31/198;C07C51/60;C07C231/02;C07C231/24;C07C233/63;(IPC1-7):A61K31/198 |
主分类号 |
A61K31/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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