Transgenic cell and animal modeling ige-mediated human allergic responses and use thereof

摘要

The invention relates to a transgenic non-human animal cell characterized in that it expresses at least one nucleotide sequence coding for at least one of the chains of human receptors of the fragment Fc of IgE immunoglobulins (FcepsilonR)) and a nucleotide sequence coding fo a human origin, characterized in that the murine gene coding for the chain Fcepsilon)R) of the human receptor is inactive. The invention also relates to a corresponding transgenic animal and a method for understanding physiopathological elements involved in immediate hypersensitivity and/or inflammatory mechanisms. The invention further relates to a method for screening active compounds on interactions between human IgE's and the receptors thereof.