| 摘要 |
Novel compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein: the dotted line represents an optional double bond; X<1 >is optionally substituted alkyl, cycloalkyl, aryl, heteroaryl or heterocycloalkyl; X<2 >is -CHO, -CN, optionally substituted amino, alkyl, or aryl; or X<1 >is optionally substituted benzofused heterocyclyl and X<2 >is hydrogen; or X<1 >and X<2 >together form an optionally benzofused spiro heterocyclyl group R<1>, R<2>, R<3 >and R<4 >are independently H and alkyl, or (R<1 >and R<4>) or (R<2 >and R<3>) or (R<1 >and R<3>) or (R<2 >and R<4>) together can form an alkylene bridge of 1 to 3 carbon atoms; Z<1 >is optionally substituted alkyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl, or -CO2(alkyl or substituted amino) or CN ; Z<2 >is H or Z<1>; Z<3 >is H oralkyl; or Z<1>, Z<2 >and Z<3>, together with the carbon to which they are attached, form bicyclic saturated or unsaturated rings; pharmaceutical compositions therefore, and the use of said compounds as nociceptin receptor inhibitors useful in the treatment of pain, anxiety, cough, asthma, depression and alcohol abuse are disclosed.
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