| 摘要 |
Disclosed is a novel anti-inflammatory pharmaceutical composition that exhibits potent and selective inhibition of the cycloooxygenase-2 (COX-2) enzyme. The formulation includes of a hops extract that exhibits COX-2 selectivity as defined by dividing the IC50 COX-2/ IC5o COX-1 concentrations that are determined by testing with the William Harvey Whole Blood Assay (WHMA), and falls in the range from about 0.011 to about 0.333. Such compositions may also optionally contain high levels of alpha acids and low levels of beta acids, some flavonoid or polyphenolic compounds, and from little to no essential oils. Such compositions are useful for treating conditions that manifest as inflammatory pain, or are impacted by the COX-2 enzyme. The recited compositions are particularly beneficial for treating osteoarthritis and rheumatoid arthritis, and can be used for chronic pain with reduced gastric side effects. |
