Methods and nucleic acids for the analysis of CpG dinucleotide methylation status associated with the development of peripheral zone prostate cancer

摘要

The present invention provides for molecular GSTP1 markers that have novel utility for the analysis of methylation patterns within the promoter region and exons 1 and 2 of the GSTP1 gene, and are further useful in methods to effectively distinguish among benign hyperplasia of the prostate and different grades of prostate cancer. Additionally, the subject molecular GSTP1 markers have novel utility for the precise localization of the zone of origin to provide sensitive, accurate and non-invasive methods for the diagnosis and/or prognosis of prostate cell proliferative disorders. The present invention has novel utility for the detection and differentiation of a cell proliferative disorder of the peripheral zone of the prostate.