发明名称 |
Cellular arrays for the identification of altered gene expression |
摘要 |
The present invention relates to the generation and use of a cellular array or a cellular array in combination with other genome-registered arrays (an array of arrays) for the determination of gene function and/or perturbation mode of action. Each cellular array consists of a number of microbial strains. Each strain comprises one reporter gene fusion made up of a gene or gene fragment operably linked to a reporter gene. Each gene or gene fragment has been "registered" or mapped to a specific location in the genome of the organism. The genome-registered collection of the invention may be used to determine alterations in gene expression under a variety of conditions. Such collections are amenable to rapid assay and may be used to confirm, correct or augment data generated from DNA micro array technology
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申请公布号 |
US2004146922(A1) |
申请公布日期 |
2004.07.29 |
申请号 |
US20040772167 |
申请日期 |
2004.02.04 |
申请人 |
GONYE GREGORY E.;HANAFEY MICHAEL K.;LAROSSA ROBERT A.;RAFALSKI J. ANTONI;VAN DYK TINA K. |
发明人 |
GONYE GREGORY E.;HANAFEY MICHAEL K.;LAROSSA ROBERT A.;RAFALSKI J. ANTONI;VAN DYK TINA K. |
分类号 |
C12N15/09;C12Q1/68;(IPC1-7):C12Q1/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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