METHOD OF DEUTERATION

摘要

A method of deuterizing a compound represented by the general formula [1]: R 1- X-R2 [1] (wherein R1 represents alkyl, etc.; R2 represents alkyl, hydroxy, etc.; and X represents carbonyl or hydroxymethylene), which comprises reacti ng the compound represented by the general formula [1] with a deuterium source in the presence of a catalyst selected among activated palladium, platinum, rhodium, ruthenium, nickel, and cobalt catalysts. By the method, deuterization, which has been conducted under severe conditions, can be conducted under neutral conditions. Even when the compound contains an unsaturated bond, it can be deuterized without reducing the unsaturated bond .