发明名称 |
Materials and methods for synthesizing stilbenes |
摘要 |
The present invention relates materials and methods for synthesizing stilbenes, and in particular to processes for the synthesis of substituted stilbenes such as combretastatin A4. The present invention relates in particular to methods which are stereoselective for either the cis or the trans isomer of the substituted stilbene, using a Perkin-type condensation of an arylacetic acid and a substituted benzaldehyde, followed by a decarboxylation reaction to produce the substituted cis-stilbenes or a Suzuki-type reaction involving a Z or E-ethenyl halide and a substituted boronic acid in the presence of a palladium catalyst to produce specifically either the Z or E-isomer of substituted stilbenes.
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申请公布号 |
US2004143023(A1) |
申请公布日期 |
2004.07.22 |
申请号 |
US20040451516 |
申请日期 |
2004.03.03 |
申请人 |
HADFIELD JOHN ANTHONY;MCGOWN ALAN THOMSON;GAUKROGER KEIRA;HEPWORTH LUCY ANNETTE;LAWRENCE NICOLAS JAMES |
发明人 |
HADFIELD JOHN ANTHONY;MCGOWN ALAN THOMSON;GAUKROGER KEIRA;HEPWORTH LUCY ANNETTE;LAWRENCE NICOLAS JAMES |
分类号 |
C07C41/30;C07C43/23;(IPC1-7):C07C43/20;A61K31/075 |
主分类号 |
C07C41/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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