| 摘要 |
PROBLEM TO BE SOLVED: To provide a microarray of high detection precision requiring no blocking treatment, and reduced in a non-specific adsorption or bonding amount of a detection objective substance. SOLUTION: In this microarray wherein a physiologically active substance is immobilized in one portion of a surface of a solid phase substrate, a layer (layer A) surface-treated for immobilizing the physiologically active substance exists on the substrate surface, a layer (layer B) comprising a substance restraining adsorption of the physiologically active substance is layered on the layer A, at least one portion of the substance forming the layer B is removed from the substrate surface in an immobilization portion for the physiologically active substance, and/or an adsorption restraining effect gets ineffective therein, and/or the physiologically active substance is infiltrated to reach to the layer A therein. The physiologically active substance is, for example, a nucleic acid, an aptamer, a protein, an antibody, an oligopeptide, a peptide nucleic acid, a sugar chain, a glycoprotein or the like. COPYRIGHT: (C)2004,JPO&NCIPI
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