Omkostningseffektiv fremgangsmåde til selektiv methylering af erythromycin A-derivater

摘要

The invention relates to a cost effective and industrially advantageous process for the selective methylation of a hydroxy group at the 6 position of erythromycin A derivative which comprised methylating the erythromycin A derivative with a methylating agent in a mixture of toluene and a ploar aprotic solvent.