摘要 |
<p>Compounds of formula (I) wherein R is methyl or difluoromethyl; X is a methylene group, ethylene, -CH=CH-, -O-CH2-, -O-(CH2)2, -O-(CH2)3-, -NH-SO2-(CH2)3-, -NH-CO-(CH2)2-, -NH-CO-(CH2)3-, N-(ethane-sulfonylamino) pyperazinyl, the N-oxidised derivatives of -CH2-CH-NH2 || the compounds of formula I and the pharmaceutically acceptable salts thereof are described.The compounds of formula I are PDE 4 inhibitors.</p> |
申请人 |
ZAMBON GROUP S.P.A.;NAPOLETANO, MAURO;PELLACINI, FRANCO;MORAZZONI, GABRIELE;MACECCHINI, SILVIA;PIPPO, LARA;HAAK, THOMAS;ALLIEVI, LEOPOLDO;MORIGGI, ERMANNO |
发明人 |
NAPOLETANO, MAURO;PELLACINI, FRANCO;MORAZZONI, GABRIELE;MACECCHINI, SILVIA;PIPPO, LARA;HAAK, THOMAS;ALLIEVI, LEOPOLDO;MORIGGI, ERMANNO |