发明名称 |
METHODS OF DIAGNOSIS AND TREATMENT OF INTERSTITIAL LUNG DISEASE |
摘要 |
The present invention provides for a method of treating pulmonary disease in a subject comprising the administration to a subject in need of such treatment a therapeutically effective amount of a formulation comprising a SP-C therapeutic. Preferably, the SP-C therapeutic is an agent selected from the group consisting of an isolated SP-C protein, an isolated nucleic acid molecule encoding a SP-C protein, a SP-C receptor-specific antibody that stimulates the activity of the receptor, or pharmaceutically acceptable composition thereof. The present invention also provides methods of producin g a mouse with a targeted disruption in a surfactant protein C (SP-C) gene. Th e present invention also provides for a transgenic mouse produced by a targete d disruption in a surfactant protein C (SP-C) gene. The present invention further provides for a cell or cell line from a transgenic mouse produced by a targeted disruption in a surfactant protein C (SP-C) gene.
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申请公布号 |
CA2507613(A1) |
申请公布日期 |
2004.07.08 |
申请号 |
CA20032507613 |
申请日期 |
2003.12.09 |
申请人 |
CHILDREN'S HOSPITAL RESEARCH FOUNDATION |
发明人 |
GLASSER, STEPHEN A.;WHITSETT, JEFFREY A. |
分类号 |
A61K38/00;A61K38/17;A61P11/00;C07K14/785;C12N15/85;(IPC1-7):C12N15/85;C12Q1/00;A01K67/027 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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