| 摘要 |
<p>A process for the preparation of a compound of formula R<1>-Y<1>-P(NR<2>R<3> )2 is provided. The process comprises reacting a compound of formula PX3 with a compound of formula HNR<2>R<3> to form a compound of formula X-P(NR<2>R<3>)2; and reacting the compound of formula X-P(NR<2>R<3>)2 with a compound of formula R<1>-Y<1>-H in the presence of a hydrocarbon solvent to form the compound of formula R<1>-Y<1>-P(NR<2>R<3> )2. R<1> represents a phosphorus protecting group; R<2> and R<3> each independently represent an alkyl, preferably a C1-6alkyl, group, or R<2> and R<3> are joined, together with the N to which they are attached, to form a 5-7 membered ring; Y<1> represents O or S, preferably O; and X represents a halogen, preferably Cl. The preferred solvent is toluene.</p> |
