发明名称 |
FREE-FLOWING SOLID FORMULATIONS WITH IMPROVED BIO-AVAILABILITY OF POORLY WATER SOLUBLE DRUGS AND PROCESS FOR MAKING THE SAME |
摘要 |
A free-flowing solid formulations of drugs or pharmaceutical agents which have poor aqueous solubility are obtained by admixing a liquid or gel composition that includes 1 to 30 per cent by weight of the drug, 5 to 60 per cent by weight of a surfactant, 10 to 40 per cent by weight of water; 1 to 20 per cent by weight of unsaturated fatty acid ester, 0 to 50 per cent by weight water miscible pharmaceutically acceptable polyol and 1 to 10 per cent by weight of phospholipid with a pharmaceutically acceptable suitable solid carrier and thereafter drying the admixture. The freeflowing powder is suitable for being formed into tablets or capsules. The drug or pharmaceutical agent is solubilized in the formulation and has significantly improved bio-availability when compared to the drug tested in its pure form. |
申请公布号 |
WO2004054540(A2) |
申请公布日期 |
2004.07.01 |
申请号 |
WO2003US38979 |
申请日期 |
2003.12.09 |
申请人 |
MICELLE LABORATORIES, INC. |
发明人 |
LI, WENJIE;ALOSIO, EDWARD;DEMA-ALA, BRICINI, FAITH (BIM);NGUYEN, AMY |
分类号 |
A61K9/00;A61K9/06;A61K9/16;A61K9/20 |
主分类号 |
A61K9/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|