PEPTIDES IMPAIRING PBX DEPENDENT GENE REGULATION

摘要

The present invention relates to peptides which impair PBX-dependent regulation of gene transcription. In particular, the invention provides the use of a peptide comprising the amino acid sequence X1 X2 X3 W M X4 X5 X6 X7 wherein the sequence X1 to X7 is an amino acid sequence comprising at least 9 amino acids, which may optionally be interrupted by one or two amino acid residues between one or more of the 9 amino acid positions defined herein; X 1 is selected from W, T, PE, KQI, VV, PQT, H, RI and absent; X2 is an amino ac id with an aromatic side chain; X3 is P or D; X4 is an amino acid with a basic side chain; X5 is an amino acid with a charged side chain; X6 is an amino ac id with a charged side chain; and X7 is an amino acid with a basic side chain o r Serine; in the manufacture of a medicament for treating or preventing a disorder in which aberrant cell division occurs.