PROCESS FOR THE DIRECT PREPARATION OF 5-ALKOXY AND 5-ACYLOXY ANALOGUES OF CAMPTHOTHECINS OR MAPPICENE KETONES

摘要

A convenient and efficient process for direct preparation of 5-alkoxy and 5-acyloxy analogues of camptothecins (anticancer compounds) and mappicine ketones (antiviral compounds) has been invented by treatment of the parent compounds with alcohols and acids respectively in the presence of ceric ammonium nitrate (CAN) at room temperature. The process is simple, economic and completed within a short period of time.