| 发明名称 |
ANTI-SICKLING AGENTS |
| 摘要 |
The provides compounds for the treatment of sickle-cell disease. In particular, the invention provides 5-membered heterocyclic anti-sickling agents that are highly effective and non~toxic, and methods for their use. T he compounds include analogues and derivatives of naturally occurring 5- hydroxymethyl-2-furfuraldehyde, 5-Ethyl-2-furfuraldehyde, 5-Methyl- 2~furfuraldehyde, and 2-furfuraldehyde, and prodrug forms of the compound.</ SDOAB>
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| 申请公布号 |
CA2507545(A1) |
申请公布日期 |
2004.06.17 |
| 申请号 |
CA20032507545 |
申请日期 |
2003.12.03 |
| 申请人 |
VIRGINIA COMMONWEALTH UNIVERSITY |
发明人 |
DANSO-DANQUAH, RICHMOND;NOKURI, SAMUEL;MUSAYEV, FAIK N.;SAFO, MARTIN K.;JOSHI, GAJANAN S.;ABRAHAM, DONALD J.;BURNETT, JAMES C. |
| 分类号 |
A61K31/34;A61K31/381;A61K31/40;A61K31/401;A61K31/66;C07D207/30;C07D417/04;(IPC1-7):C07D207/30;C07D307/34 |
主分类号 |
A61K31/34 |
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