摘要 |
<p>Disclosed are the preparation and pharmaceutical use of novel noncyclic 1,3-dicarbonyl compounds of formula I, wherein ring A, ring B, R', R2, R3, R4, R5, X, Y, Z, Q, Ar and n are as defined in the specification. These compounds, as peroxisome proliferator-activated receptor (PPAR) dual agonists for both RXR/PPARgamma and RXRIPPARalpha heterodimers, are useful in the treatment and/or prevention of type 2 diabetes and associated metabolic syndrome such as hypertension, obesity, insulin resistance, hyperlipidemia, hyperglycemia, hypercholesterolemia, atherosclerosis, coronary artery disease, and other cardiovascular disorders.</p> |
申请人 |
SHENZHEN CHIPSCREEN BIOSCIENCES LTD. |
发明人 |
LU, XIAN-PING;LI, ZHIBIN;LIAO, CHENZHONG;SHI, LEMING;LIU, ZHENDE;NING, ZHIQIANG;SHAN, SONG;DENG, TUO;MA, BAOSHUN |