PRAMYXOVIRUS VECTORS ENCODING ANTIBODY AND UTILIZATION THEREOF

摘要

It is intended to provide a paramyxovirus vector expressing a polypeptide containing antibody variable regions. This vector, which encodes antibody H chain and L chain variable regions, expresses these antibody chains at the same time to form Fab. Also, a single-stranded antibody is successfully expressed at a high level. The above vector is appropriately usable as a gene therapeutic vector to be administered to a living body either in vivo or ex vivo. In particular, a vector expressing an antibody fragment against nerve elongation inhibitor is useful in treating nerve injury. The above vector expressing an antibody which inhibits immunopotentiation signal transfer enables the prolonged expression of a gene from the vector.