发明名称 MODIFYING EXPRESSION OF FSHbeta GENE USING HOMOLOGOUS RECOMBINATION
摘要 FIELD: molecular genetics. SUBSTANCE: invention represents isolated nucleic acid molecule that is hybridized under rigid conditions or shows 80% level of identity with defined genome site located above the encoding segment of FSHbeta gene, and also DNA construction comprising this nucleic acid molecule as a directing sequence for providing the homologous recombination. EFFECT: expanded assortment of genetic therapeutic agents. 18 cl, 12 dwg, 1 tbl
申请公布号 RU2229309(C2) 申请公布日期 2004.05.27
申请号 RU20000130730 申请日期 1999.05.05
申请人 发明人 TREKO DUGLAS A.;KHARTLEJN MAJKL V.;SELDEN RICHARD F.
分类号 C12N15/09;A61K48/00;A61P5/06;A61P5/24;C07K14/59;C12N5/10;C12N15/67;C12N15/85 主分类号 C12N15/09
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