发明名称 |
Mice lacking inward-rectifying potassium channel Kir6.1 |
摘要 |
Mice homozygous for the lack of inward-rectifying potassium channel Kir6.1 gene are disclosed. The mice causes a high incidence of sudden death associated with arrhythmia (atrioventricular block) caused by spontaneous cardiac ischemia, a condition similar to Prinzmetal angina (variant angina) in human, representing an animal model of Prinzmetal angina. Mice heterozygous for the lack of inward-rectifying potassium channel Kir6.1 gene are also disclosed, which are used as parent mice for reproduction of the homozygous mice.
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申请公布号 |
US2004098757(A1) |
申请公布日期 |
2004.05.20 |
申请号 |
US20030388005 |
申请日期 |
2003.03.14 |
申请人 |
JCR PHARMACEUTICALS CO., LTD. |
发明人 |
SEINO SUSUMU;MIKI TAKASHI;NAKAYA HARUAKI |
分类号 |
A01K67/027;C07K14/705;C12N5/10;C12N15/09;C12N15/85;(IPC1-7):A01K67/027;C12N5/06 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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