| 摘要 |
A porous composite matrix is formed from a hyaluronic acid derivative and hydrolyzed collagen, which are preferably in a weight ratio range of 30:70 to 99:1. A preferred hyaluronic acid derivative is an ester such as an ethyl or benzyl ester. The matrix is prepared by dissolving the hyaluronic acid derivative and hydrolyzed collagen in a first solvent, adding a pulverulent compound virtually insoluble in the first solvent, removing the first solvent, and dissolving the pulverulent compound in a second solvent. The matrix is used as a biocompatible and biodegradble composite matrix for the tissue engineering of chondral and osseous tissue and for the repair of muscoskeletal defects.
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