INHIBITORS OF GSK-3 AND CRYSTAL STRUCTURES OF GSK-3 beta PROTEIN AND PROTEIN COMPLEXES

摘要

The present invention relates to inhibitors of GSK-3 and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors and methods of utilizing those compositions in the treatment and prevention of various disorders, such as diabetes and Alzheimer's disease. In addition, the invention relates to molecules or molecular complexes which comprise binding pockets of GSK-3 beta or its homologues. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to GSK-3 beta protein or homologues thereof. The invention also relates to crystallizable compositions and crystals comprising GSK-3 beta protein or GSK-3 beta protein complexes.