A sublingual composition comprising fentanyl adhered to microparticles for the treatment of acute pain

摘要

A pharmaceutical composition for the treatment of acute pain by sublingual administration comprises an essentially water-free, ordered mixture of microparticles of fentanyl or a pharmaceutically acceptable salt thereof adhered to the surfaces of carrier particles and a bioadhesion and/or mucoahesion promoting agent mainly adhered to the surfaces of the carrier particles. The carrier particles being substantially larger than the microparticles of fentanyl and are essentially water-soluble.