| 摘要 |
<p>The present invention relates to a composition comprising a sterile ophthalmic composition, which comprises one or more agents capable of inhibiting lens epithelial proliferation (e.g. fluorouracil, saporin, mitomycin or doxorubicin), dissolved in a physiologically isotonic solution. The present invention also relates to a method of preventing capsular opacification by using said composition. The method comprises the steps of : creating an incision within an eye and a capsulorhexis in a capsular bag of said eye; inserting at least a portion of cannula in said capsulorhexis; separating the natural crystalline lens from the capsular bag by injecting through a cannula the composition in a manner that generates a space between the capsular bag and the natural crystalline lens; retaining the composition in said space between the capsule and the natural crystalline lens for a sufficient time for said composition to effectively kill or render non-proliferative lens epithelial cells in or adjacent to said space; removing the lens and said composition; inserting an implant into the capsular bag.</p> |
