发明名称 New receptor protein, useful for detecting specific-binding aldehydes or their antagonists that can be used as contraceptives and conception-promoting agents
摘要 Receptor protein (RP) that is (a) a segment of sequences (4; 312 amino acids (aa)) or (8; 350 aa); (b) a segment with sequence homology with (a) of over 70% or (c) a fragment of (a) or (b), is new. Independent claims are also included for the following: (1) receptor (R1) having a structure that binds specifically to agonists (A) that contain an aldehyde group in which the C atom is linked to an aromatic residue (Ar) through a chain of 1-3 atoms, one of which may be oxygen and the others C, with each C in the chain independently linked to one or two Me, and Ar is optionally substituted once by Me, Et, OMe, OEt, isopropyl ot tert-butyl; (2) receptor (R2) able to bind specifically to n-undecanal; (3) vector comprising a nucleic acid segment (NA) that encodes RP or R1; (4) expression system comprising a cell that over expresses RP or R1; (5) complex (C) comprising RP or R1, bound to an agonist (A1) or antagonist (An) of the binding of A1; (6) biosensor comprising RP or R1 and a system for detecting binding of A1; (7) probe for detecting NA; (8) method for preparing RP or R1; and (9) method for detecting A1 or An.
申请公布号 DE10246329(A1) 申请公布日期 2004.04.15
申请号 DE20021046329 申请日期 2002.10.04
申请人 SYMRISE GMBH & CO. KG 发明人 HATT, HANNS
分类号 A61K31/11;C07K14/705;(IPC1-7):C07K14/705;C12Q1/25 主分类号 A61K31/11
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