METHODS OF SCREENING COMPOUNDS FOR GRK6 MODULATING ACTIVITY
摘要
The present invention relates to methods of treating disease by altering G protein coupled receptor kinase (GRK) 6. This may be done by altering the expression or activity of the protein, for example. The present invention may be used for disease diagnosis, by detecting the expression or activity of GRK6. The present invention relates to a GRK6 deficient mouse, GRK6 splice variants, and methods of use. The present invention also relates to methods of identifying compounds that alter GRK6 activity. The present invention relates to disease treatment by altering GRK6 expression or activity.
申请公布号
WO2004004451(B1)
申请公布日期
2004.04.15
申请号
WO2003US20838
申请日期
2003.07.03
申请人
DUKE UNIVERSITY;CARON, MARC, G.;GAINETDINOV, RAUL, R.;LEFKOWITZ, ROBERT, J.;PREMONT, RICHARD, T.
发明人
CARON, MARC, G.;GAINETDINOV, RAUL, R.;LEFKOWITZ, ROBERT, J.;PREMONT, RICHARD, T.
