| 发明名称 |
IDENTIFICATION OF A PHAGE ASSOCIATED LYTIC ENZYME TO RAPIDLYAND SPECIFICALLY DETECT AND KILL BACILLUS ANTHRACIS |
| 摘要 |
A method and composition for treating a Bacillus anthracis infection is disclosed which comprises the steps of: administering to the site of an infection or colonization an effective amount of at least one lytic enzyme genetically coded for by a bacteriophage specific for Bacillus anthracis, wherein said at least one said lytic enzyme is specific for and has the ability to digest a cell wall of said Bacillus anthracis. The lytic enzyme m ay be chimeric or shuffled, and a holin protein may also be used. The sequence for the lytic enzyme gamma bacteriophage is disclosed.
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| 申请公布号 |
CA2486280(A1) |
申请公布日期 |
2004.04.01 |
| 申请号 |
CA20032486280 |
申请日期 |
2003.05.19 |
| 申请人 |
NEW HORIZONS DIAGNOSTICS CORPORATION;THE ROCKEFELLER UNIVERSITY |
发明人 |
FISCHETTI, VINCENT A.;NELSON, DANIEL;SCHUCH, RAYMOND;LOOMIS, LAWRENCE;TRUDIL, DAVID |
| 分类号 |
A61K31/00;A61K31/197;A61K38/46;A61K38/48;A61K45/06;C07K14/01;C07K14/32;C12N9/14;C12N9/48;C12N9/80;C12Q1/04;G01N33/66;(IPC1-7):C12N15/57;C12N15/33;C12Q1/37;C12N9/50;A61K35/76 |
主分类号 |
A61K31/00 |
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