发明名称 |
Fibrin/fibrinogen-binding conjugate |
摘要 |
A fibrin/fibrinogen binding conjugate for forming a depot for the sustained release of a pharmaceutically active substance from a fibrin clot. The conjugate comprises a fibrin/fibrinogen binding moiety bound to a pharmaceutically active substance either directly or via an intervening substance capturing moiety such as an antibody. The conjugate can also be a recombinant fusion protein comprising a fibrin/fibrinogen binding moiety such as VEGF165 C-terminal domain fused to a wound-healing substance such as leptin.
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申请公布号 |
US6713453(B2) |
申请公布日期 |
2004.03.30 |
申请号 |
US20010963156 |
申请日期 |
2001.09.25 |
申请人 |
BAXTER AKTIENGESELLSCHAFT;BAXTER INTERNATIONAL INC. |
发明人 |
REDL HEINZ;FUERST WALTER;KNEIDINGER RUDOLF;HELGERSON SAM L.;LOOKER DOUGLAS;INMAN ELISABETH M.;RICHARDS JANE P.;WONG CATALINA |
分类号 |
A61K47/42;A61K38/00;A61K47/48;C07K14/475;C07K14/50;C07K14/705;C07K14/745;C07K14/75;C07K14/78;C07K16/00;C07K19/00;C12N15/12;(IPC1-7):A61K38/18 |
主分类号 |
A61K47/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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