发明名称 |
COMPOSITIONS COMPRISING GENOME SEGMENTS AND METHODS OF USING THE SAME |
摘要 |
Methods of treating an individual who has a disease or disorder associated with one or more genetic mutations or undersirable alleles in genomic DNA of the individual, or preventing an individual from developing a disease or disorder associated with one or more genetic mutations or undesirable alleles in genomic DNA of the individual, by replacing a segment of genomic DNA that has a mutated sequence or undesirable allele with a corresponding segment of DNA that has a non-mutated sequence or desirable allele, are disclosed. Methods of inducing tolerance and preventing transplant rejection in a recipient, methods of inducing tolerance and or reducing allergies are disclosed and method of increasing fertility in a woman are disclosed. Each of the methods comprises replacing a segment of genomic DNA in an individual with a corresponding segment of DNA from another. An apparatus for doing large scale PCR preparations is disclosed. Pharmaceutical compositions that comprise a plurality of polynucleotide molecules which collectively comprise an essentially complete genome in polynucleotide molecules having about 100-3000 nucleotides are disclosed.
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申请公布号 |
WO0149118(A8) |
申请公布日期 |
2004.03.25 |
申请号 |
WO2001US00143 |
申请日期 |
2001.01.03 |
申请人 |
PANAGENIC INTERNATIONAL, INC.;YAKUBOV, LEONID, A. |
发明人 |
YAKUBOV, LEONID, A. |
分类号 |
A61K48/00;(IPC1-7):A01N43/04 |
主分类号 |
A61K48/00 |
代理机构 |
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