发明名称 |
TRANSGENIC AVES PRODUCING HUMAN POLYCLONAL ANTIBODIES |
摘要 |
Human antibodies are produced in transgenic chickens having functional genetic components of the human immune system stably integrated in the genome. Techniques are described to integrate unrearranged human heavy and light chain immunoglobulin loci into the genome of the transgenic chicken. The functional description of the endogenous immunoglobulin loci yields an animal whose antibody repertoire in response to antigen is fully human. In the preferred embodiment, the human immunoglobulin locus is at least as large as the native human locus and exhibits functional class switching to yield IgG isotype antibodies. In addition to monoclonal antibodies secreted from immortalized B cell populations, polyclonal antibodies may be obtained from eggs laid by the transgenic chickens of the invention. |
申请公布号 |
WO03081993(A3) |
申请公布日期 |
2004.03.25 |
申请号 |
WO2003US09288 |
申请日期 |
2003.03.24 |
申请人 |
ORIGEN THERAPEUTICS |
发明人 |
ETCHES, ROBERT, J.;KAY, ROBERT, M.;LEIGHTON, PHILIP;ZHU, LEI |
分类号 |
A01K67/027;C07K14/705;C07K16/02;C12N5/06;C12N15/85 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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