发明名称 |
Method for preparing and using polyoxyethylated castor oil in pharmaceutical compositions |
摘要 |
A method is provided for preparing a pharmaceutical composition comprising: taking polyoxyethylated castor oil which if diluted 1:10 in water has a pH greater than 5 and aging the polyoxyethylated castor oil by exposing the polyoxyethylated castor oil to a gas comprising oxygen for a period of time, the exposure to the gas over the period of time causing an acidity of the polyoxyethylated castor oil to increase; and forming a pharmaceutical composition comprising the aged polyoxyethylated castor oil and a pharmaceutically active agent such as paclitaxel; wherein at least 80% of the potency of the pharmaceutically active agent is retained by the pharmaceutical composition after the pharmaceutical composition is stored for at least 7 days at 40° C.
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申请公布号 |
US6710195(B2) |
申请公布日期 |
2004.03.23 |
申请号 |
US20020306824 |
申请日期 |
2002.11.26 |
申请人 |
SUPERGEN, INC. |
发明人 |
JOSHI-HANGAL RAJASHREE;RUBINFELD JOSEPH;REDKAR SANJEEV;GORE ASHOK Y. |
分类号 |
A61K9/08;A61K9/00;A61K31/337;A61K36/47;A61K47/10;A61K47/22;A61K47/34;A61K47/44;A61K47/46;A61P35/00;(IPC1-7):C07C51/16 |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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