INDUCTION OF ANTIGEN SPECIFIC IMMUNOLOGIC TOLERANCE
摘要
Antigen specific immune tolerance is induced in a mammalian host by administration of a toleragen in combination with a regimen of immunosuppression. The methods optionally include a preceding conditioning period, where immunosuppressive agents are administered in the absence of the toleragen. After the tolerizing regimen, the host is withdrawn from the suppressive agents, but is able to maintain specific immune tolerance to the immunogenic epitopes present on the toleragen. Optimally, the toleragen will have high uptake properties that allow uptake in vivo at low concentrations in a wide variety of tolerizing cell types.
申请公布号
WO03094840(A3)
申请公布日期
2004.03.11
申请号
WO2003US13843
申请日期
2003.05.05
申请人
BIOMARIN PHARMACEUTICAL INC.;HARBOR-UCLA RESEARCH AND EDUCATION INSTITUTE;KAKKIS, EMIL, D.;PASSAGE, MERRY;LESTER, THOMAS;YANG, REBECCA;TANAKA, CHRISTOPHER
发明人
KAKKIS, EMIL, D.;PASSAGE, MERRY;LESTER, THOMAS;YANG, REBECCA;TANAKA, CHRISTOPHER