| 摘要 |
The present invention provides an antiproliferative compound having a structural formulawhere X and Y independently are oxygen, nitrogen o r sulfur; R<1 >is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester, thioamide, thiolacid, thiolester, saccharide, alkoxy-linked saccharide, amine, sulfonate, sulfate, phosphate, alcohol, ethers or nitriles; R<2 >and R<3 >are hydrogen or R<4>; R<4 >is methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide or amine; and R<5 >is alkenyl; where when Y is nitrogen, said nitrogen is substituted with R<6>, wherein R<6 >is hydrogen or methyl. Also provided are methods for treating a cell proliferative disease and for inducing apoptosis in a cell comprising administering this compound is also provided.
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