发明名称 |
Derivatives of isosorbid mononitrate and its use as vasodilating agents with reduced tolerance |
摘要 |
Disclosed are derivatives of isosorbid mononitrate and pharmaceutically acceptable salts thereof which have a vasodilator activity with a reduced tolerance effect, having the general formula (I) wherein A and B represent independently any of the groups NO2 and-CO-R, Z being an atom of oxygen or sulfur, and R being optionally substituted C1-C4 alkyl, aryl or aralkyl group or the group (a) wherein R1 is hydrogen or optionally substituted C1-C4 alkyl, aryl or aralkyl group,so that always either A or B is NO2 but never both at the same time, when Z is a sulfur atom R is optionally substituted C1-C4 alkyl, aryl or aralkyl group, and when Z is an oxygen atom R is the group (a).
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申请公布号 |
NZ510855(A) |
申请公布日期 |
2004.02.27 |
申请号 |
NZ19990510855 |
申请日期 |
1999.10.04 |
申请人 |
LACER, S |
发明人 |
NEGRIE ROFES, CRISTINA;CERDA RIUDAVETS, JUAN ANTONIO;ERRER SISO, ALICIA;RADOMSKI, MAREK W;SALAS PEREZ-RASILLA,EDUARDO;MARTINEZ BONNIN, JUAN;REPOLLES MOLINER, JOSE;UBILL COY, FRANCISCO;CABEZA LLORENTE, LYDIA;CARBO BANUS,MARCEL |
分类号 |
A61K31/34;A61P9/10;C07D493/04;(IPC1-7):C07D493/04 |
主分类号 |
A61K31/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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