METHODS FOR IDENTIFYING MODULATORS OF RECEPTOR TYROSINE KINASES

摘要

Screening methods for identifying small molecules capable of binding to the juxtamembrane-kinase interaction (JKI) site of the tyrosine kinase domain of the insulin receptor (IRK) to prevent or lessen constitutive inhibition of kinase activity. More generally, the invention relates to screening methods for identifying small molecules capable of binding to the JKI site of a tyrosine kinase domain, to modulate kinase activity in a receptor molecule comprising a JKI site.