发明名称 |
Inhibitors of spermidine synthase for the treatment of osteoarthritis and cartilage rehabilitation |
摘要 |
This invention provides a method for the treatment of a subject in need of treatment for osteoarthritis comprising administering to said subject an amount of an inhibitor of spermidine biosynthesis sufficient to effect a substantial inhibition of spermidine biosynthesis. This invention also provides the use of an inhibitor of spermidine biosynthesis in the treatment of a subject in need of treatment of osteoarthritis in an amount sufficient to effect a substantial inhibition of spermidine biosynthesis. This invention further provides a method of preparing a therapeutic composition for the treatment of a subject in need of a treatment for osteoarthritis and the invention further provides a method of identifying an inhibitor of spermidine biosynthesis, whereby the inhibitor is a spermidine synthase inhibitor.
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申请公布号 |
US6696454(B2) |
申请公布日期 |
2004.02.24 |
申请号 |
US20010023038 |
申请日期 |
2001.12.12 |
申请人 |
QUARK BIOTECH, INC.;SHIONOGI & CO., LTD. |
发明人 |
BAR DGANIT;FEINSTEIN ELENA;SEGEV ORIT |
分类号 |
G01N33/50;A61K31/13;A61K31/155;A61K31/16;A61K31/275;A61K31/52;A61K31/70;A61K31/7076;A61K45/00;A61P19/02;A61P43/00;C12N9/99;C12Q1/02;C12Q1/48;C12Q1/527;G01N33/15;(IPC1-7):B32B17/03 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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