| 摘要 |
Novel compounds useful as chemotherapeutic, chemopreventive, and antiangiogenic agents are provided. The compounds are flavanoids, including flavanones, flavanols, and chalcones. The compounds have the structure of formula (I), wherein R<1> through R<3> and R<5 >through R<11> are defined herein, and alpha, beta and gamma are optional bonds, providing that when alpha is absent, beta is present, and when beta is absent, alpha is present. When alpha is present, preferred R<4> moieties are selected from O, S, NH and CH2, and when alpha is absent, preferred R<4> groups are selected from OH, SH, NH2 and CH3. When gamma is present, the preferred R<5> substituent is O, while when gamma is absent, the preferred R<5> substituent is OH. Pharmaceutical compositions are provided as well, as are methods of synthesis and use. |
