A conjugate of formula (1); wherein the moiety A-O- is the residue of any anthracycline of formula A-O-H bearing at least one primary or secondary hydroxyl group; a is an integer of from 1 to 30; W is a residue of formula (2), wherein B represents a C1-C6 alkylene group optionally hetero interrupted and m is 0 or 1; Z is a spacer group and T is a carrier moiety. The conjugates of formula (1) of the present invention are useful antitumor agen ts since they contain an acetalic bond which releases the parent drug A-O-H upon hydronium-ion-catalyzed hydrolysis or "in vivo" enzymatic cleavage.
申请公布号
CA2075288(C)
申请公布日期
2004.02.17
申请号
CA19912075288
申请日期
1991.12.03
申请人
FARMITALIA CARLO ERBA S.R.L.
发明人
ANGELUCCI, FRANCESCO;RUGGIERI, DANIELLA;STEFANELLI, STEFANIA;SUARATO, ANTONINO;BERSANI, LAURA