发明名称 |
METHODS FOR THE PRODUCTION OF CELLS AND MAMMALS WITH DESIRED GENETIC MODIFICATIONS |
摘要 |
The present invention features novel methods for generating cell lines and mammals with site-specific genetic modifications of interest. The methods involve homologous recombination between an artificial chromosome having a modification of interest and an endogenous chromosome of a cell. The resulting modified cells can be used in standard methods to generate genetically modified mammals. These mammals can be used in a variety of screening methods to identify compounds useful for the treatment or prevention of disease. Additionally, cells that have been modified to eliminate a mutation associated with a disease can be transplanted into patients for the treatment of a disease. |
申请公布号 |
WO2004013299(A2) |
申请公布日期 |
2004.02.12 |
申请号 |
WO2003US24322 |
申请日期 |
2003.08.01 |
申请人 |
THE GENERAL HOSPITAL CORPORATION;SEED, BRIAN;YANG, YI |
发明人 |
SEED, BRIAN;YANG, YI |
分类号 |
C12N15/90 |
主分类号 |
C12N15/90 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|