| 摘要 |
Compounds of formula (I) or a derivative thereof, wherein; R is C1-6allkyl, C3-7cycloalkyl, C1-6alkoxy, hydroxy, halo, C1-6alkenyl, C1-6allkynyl, amino, C1-6alkylamino, di(C1-6alkyl)amino, hydroxyC1-6alkyl, C1-6akoxyC1-6alkyl, aminoC1-6allkyl, (C1-6allkyl)aminoC1-6alkyl, di(C1-6allkyl)aminoC1-6alkyl; R<1 >is hydrogen or R; R<2 >is hydroxy, C1-6alkoxy, amino, C1-6alkylamino, di(C1-6alkyl)amino; R<3 >is hydrogen or C1-6alkyl; R<4 >and R<5 >are each independently selected from the list consisting of perhaloC1-6alkyl, hydrogen, halo, C1-6alkyl, C1-6alkoxy, hydroxy, amino, C1-6akylamino, di(C1-4alkyl)amino, hydroxyC1-6alkyl, C1-6akoxyC1-6alkyl, aminoC1-6allkyl, (C1-4alkyl)aminoC1-6alkyl, di(C1-4alkyl)aminoC1-4alkyl, aryl, and COX wherein X may be hydroxy, C1-6alkoxy, C1-6alkyl, amino, C1-6alkylamino, or di(C1-6allkyl)amino; with the proviso that, when R<3 >is hydrogen, then R R<4 >and R<5 >are not both hydrogen; and wherein any alkyl group or the alkyl moiety of any group containing such a moiety may be substituted one or more times by halo; are ligands of the ORL-1 receptor and are useful in therapy.
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