发明名称 |
Para-hydrogen labeled agents and their use in magnetic resonance imaging |
摘要 |
The invention provides a method of magnetic resonance investigation of a sample, said method comprising: (i) reacting para-hydrogen enriched hydrogen with a hydrogenatable MR imaging agent precursor containing a non-hydrogen non-zero nuclear spin nucleus to produce a hydrogenated MR imaging agent; (ii) administering said hydrogenated MR imaging agent to said sample; (iii) exposing said sample to radiation of a frequency selected to excite nuclear spin transitions of said non-zero nuclear spin nucleus in said hydrogenated MR imaging agent; (v) detecting magnetic resonance signals of said non-zero nuclear spin nucleus from said sample; and (vi) optionally, generating an image or biological functional data or dynamic flow data from said detected signals.
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申请公布号 |
US2004024307(A1) |
申请公布日期 |
2004.02.05 |
申请号 |
US20030395002 |
申请日期 |
2003.03.24 |
申请人 |
AMERSHAM HEALTH AS |
发明人 |
GOLMAN KLAES;AXELSSON OSKAR;JOHANNESON HAUKUR;OLOFSSON CHARLOTTE;MANSSON SVEN;PETERSSON STEFAN |
分类号 |
G01R33/28;A61B5/055;A61K;A61K49/00;A61K49/06;A61K49/08;A61K49/18;A61K51/04;C07B35/02;C07B59/00;C07C15/04;C07C15/067;C07C57/22;C07C69/606;C10G45/32;G01R33/62;(IPC1-7):A61B5/05 |
主分类号 |
G01R33/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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