发明名称 |
Tocopherol associated protein and uses thereof |
摘要 |
The present invention provides a novel tocopherol associated protein (TAP-38) DNA/protein with a 76 nucleotide base deletion resulting in a 25 amino acid deletion, followed by 90 novel nucleotides that code for 30 novel amino acids that are not expressed by TAP-46. The present invention provides data showing that TAP-38 enhances the apoptotic inducing properties of tocopherol based compounds, and blockage of TAP reduces the effectiveness of tocopherol based compounds. Thus, the present invention claim that expression of TAP-38 by tumor cells enhances the apoptotic inducing properties of tocopherol based compounds. The present invention provides aerosol liposome/transfection/infection methods for delivery of TAP-38 and TAP-46 cDNA plasmids separately and in combination with tocopherol based apoptotic inducing agents as well as with other chemotherapeutic agents as a method for treatment and prevention of cellular proliferative diseases and disorders.
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申请公布号 |
US2004023915(A1) |
申请公布日期 |
2004.02.05 |
申请号 |
US20030419629 |
申请日期 |
2003.04.21 |
申请人 |
SANDERS BOB G.;KLINE KIMBERLY;YU WEIPING;LIU HUI;HANTASH FERAS |
发明人 |
SANDERS BOB G.;KLINE KIMBERLY;YU WEIPING;LIU HUI;HANTASH FERAS |
分类号 |
A61K48/00;C07K14/47;(IPC1-7):A61K48/00;C07H21/04;C12N9/02;C12P21/02;C12N5/06 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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