发明名称 Tocopherol associated protein and uses thereof
摘要 The present invention provides a novel tocopherol associated protein (TAP-38) DNA/protein with a 76 nucleotide base deletion resulting in a 25 amino acid deletion, followed by 90 novel nucleotides that code for 30 novel amino acids that are not expressed by TAP-46. The present invention provides data showing that TAP-38 enhances the apoptotic inducing properties of tocopherol based compounds, and blockage of TAP reduces the effectiveness of tocopherol based compounds. Thus, the present invention claim that expression of TAP-38 by tumor cells enhances the apoptotic inducing properties of tocopherol based compounds. The present invention provides aerosol liposome/transfection/infection methods for delivery of TAP-38 and TAP-46 cDNA plasmids separately and in combination with tocopherol based apoptotic inducing agents as well as with other chemotherapeutic agents as a method for treatment and prevention of cellular proliferative diseases and disorders.
申请公布号 US2004023915(A1) 申请公布日期 2004.02.05
申请号 US20030419629 申请日期 2003.04.21
申请人 SANDERS BOB G.;KLINE KIMBERLY;YU WEIPING;LIU HUI;HANTASH FERAS 发明人 SANDERS BOB G.;KLINE KIMBERLY;YU WEIPING;LIU HUI;HANTASH FERAS
分类号 A61K48/00;C07K14/47;(IPC1-7):A61K48/00;C07H21/04;C12N9/02;C12P21/02;C12N5/06 主分类号 A61K48/00
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