METHOD FOR SOLUBILIZING HYDROPHOBIC PEPTIDES AND USE THEREOF FOR INDUCING AN ANTITUMORAL AND/OR ANTI-INFECTIOUS CTL RESPONSE
摘要
The invention concerns a molecule of pharmaceutical interest, preferably a hydrophobic major histocompatibility complex (MHC) ligand soluble in solvents such as DMSO, solubilized in an aqueous medium capable of being injected into a human being for preparing a pharmaceutical composition designed to induce an immune response mediated by cytotoxic T lymphocytes. The invention also concerns the use of such peptides mixed or coupled with a carrier protein for preparing a vaccine composition for preventing infectious diseases or for treating cancers. The invention further concerns said peptides, in particular as anti-infectious or antitumoral medicine.
申请公布号
WO2004011486(A2)
申请公布日期
2004.02.05
申请号
WO2003FR02353
申请日期
2003.07.25
申请人
PIERRE FABRE MEDICAMENT;BECK, ALAIN;CORVAIA, NATHALIE;KLINGUER-HAMOUR, CHRISTINE;GOETSCH, LILIANE;HAEUW, JEAN-FRANCOIS