发明名称 |
PROTAMINE-ADENOVIRAL VECTOR COMPLEXES AND METHODS OF USE |
摘要 |
Embodiments of the invention include methods and compositions including viral composition that have high transduction efficiencies in vivo, in vitro and ex vivo. The viral composition include a viral vector and a protamine molecule, wherein the viral vector includes a polynucleotide encoding a tumor suppressor gene. The methods of the invention include administering the viral composition to a patient or subject for treatment of disease, in particular cancer, that is characterized by a reduced vector-induced production of neutralizing antibodies and a decreased vector-induced toxicity as compared to delivery of viral vectors alone.
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申请公布号 |
WO03082195(A9) |
申请公布日期 |
2004.02.05 |
申请号 |
WO2003US09152 |
申请日期 |
2003.03.24 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;JI, LIN;ROTH, JACK, A. |
发明人 |
JI, LIN;ROTH, JACK, A. |
分类号 |
A61K38/17;A61K47/48;A61K48/00;C12N15/86;C12N15/861;(IPC1-7):A61K/ |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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