| 摘要 |
FIELD: medicine, pharmaceutical industry, pharmacy. ^ SUBSTANCE: invention relates to a method for preparing solid pharmaceutical composition used for oral administration. Method involves stages for preparing granules I with the direct release, preparing floating granules II with regulated release, pressing granules I and II to obtain bi-layer tablets and applying a film coating on bi-layer tablets. Also, invention describes a solid pharmaceutical composition used for oral administration that comprises two or more layers wherein the first layer is designated for the direct release of an active substance without temporal delaying in treatment, and the second layer is formed by matrix that releases a medicinal preparation with regulated release as long as this system floats in the stomach medium. ^ EFFECT: valuable medicinal and pharmaceutical properties of composition. ^ 21 cl, 3 tbl, 1 dwg, 3 ex |
