| 摘要 |
PURPOSE:To remove an allyl group of an allyl ester of a penem compound by reacting the allyl ester of a penem compound with a carboxylic acid alkali metal salt in the presence of palladium acetate and a trialkyl phosphite. CONSTITUTION:A compound of formula I [(m) is 0 or 1; R<1> is (substituted)allyl] is reactel with an alkali metal salt of 1-8C carboxylic acid or 1-8C carboxylic acid and an alkali metal salt in the presence of palladium acetate and a trialkyl phosphite in a solvent (e.g. THF) at ambient temperature to provide a compound o formula II (R<2> is alkali metal) by removing the allyl group. The allyl group of allyl ester of the penem compound of formula I can rapidly be removed in high yield using a relatively inexpensive raw material stable in air. The allyl group is used as protective group for carboxyl group, etc., in the synthesis of beta-lactam-based antibiotic. |
