EXPERIMENTAL ANIMALS FOR EVALUATION OF THERAPEUTIC EFFECTS ON CORNEAL EPITHELIAL DAMAGES

摘要

An excellent model animal having a corneal epithelial damage, an excellent method of evaluating a medicine using the model animal, and an excellent medicine selected by the evaluation method are provided. A model animal having a corneal epithelial damage, characterized in that the corneal epithelial damage is caused by contacting an ocular cornea of the animal with a water-absorbing material and thereby generating the difference in osmotic pressure between the inside and outside of corneal epithelium cells; a method of evaluating a medicine characterized by using the model animal; and a medicine selected by the evaluation method.