发明名称 |
METHODS AND COMPOSITIONS FOR MODULATING AND DETECTING WISP ACTIVITY |
摘要 |
<p>Methods and compositions for use in modulating the activity(s) of WISP-1 polypeptide are provided. WISP-1 antagonists include anti-WISP-1 antibodies, WISP-1 immunoadhesins and WISP-1 variants (and fusion proteins thereof) whic h inhibit or neutralize induction or secretion of HAS2, HA, CD44 or RHAMM by native human WISP-1 polypeptide in at least one type of mammalian cell. The invention also provides methods for in vitro, in situ, and/or in vivo diagnosis and/or treatment of mammalian cells or pathological conditions associated with native WISP-1 polypeptides.</p> |
申请公布号 |
CA2489515(A1) |
申请公布日期 |
2004.01.08 |
申请号 |
CA20032489515 |
申请日期 |
2003.06.28 |
申请人 |
GENENTECH, INC. |
发明人 |
DESNOYER, LUC;FILVAROFF, ELLEN |
分类号 |
A61K39/00;C07K14/47;C07K16/22;C07K16/30;(IPC1-7):C12N5/12;C07K16/18;G01N33/53;C07K14/435;A61K39/395;G01N33/574;A61K38/17;C12Q1/02;A61P35/00;C07K19/00 |
主分类号 |
A61K39/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|